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More than 100 mesothelioma clinical trials are currently accepting patients. Active, recruiting clinical trials accept mesothelioma cancer patients who meet certain eligibility criteria. Doctors can help interested patients understand eligibility and enrollment. Accepted patients often gain access to new and emerging therapies. 


01. Actively Recruiting Clinical Trials

Mesothelioma Clinical Trials Currently Accepting Patients

Mesothelioma patients may consider participating in a clinical trial. Clinical trials are medical studies involving people. There are dozens of active clinical trials recruiting mesothelioma patients who meet the eligibility requirements.

Doctors use mesothelioma clinical studies to evaluate the safety and efficacy of new treatments. If treatments perform well in clinical trials, they can go on to become approved by the U.S. Food and Drug Administration (FDA).

One example of this is the immunotherapy combination of Opdivo® and Yervoy®. Together, these drugs proved successful in clinical trials. Researchers found the combination extended patient survival. Based upon that data, the FDA approved Opdivo® and Yervoy® for the treatment of inoperable pleural mesothelioma.

Emerging Treatments in Mesothelioma Clinical Trials

  • Cancer vaccines: A type of immunotherapy that teaches the immune system to attack cancer, much like a vaccine
  • Cryotherapy: A cancer treatment that uses extremely cold material to treat mesothelioma
  • Immunotherapy: A wide variety of treatments that use the immune system to fight cancer
  • Multimodal therapy: Various combinations of two or more mesothelioma treatments
  • Photodynamic therapy: A treatment that uses light to kill cancer cells
  • Radical surgery: Aggressive surgical removal of mesothelioma tumors

These important medical studies follow a defined process. Each mesothelioma clinical trial starts with an idea, often in a research laboratory. Treatments that perform well in the lab and in animals can move on to clinical trials testing. This is the point at which researchers allow people to volunteer to help evaluate the new treatment(s).

Mesothelioma patients with limited treatment options may be able to access new treatments through clinical trials. In fact, the American Society of Clinical Oncology (ASCO) recommends clinical trial enrollment for the following pleural mesothelioma patients:

  • Patients qualifying for a second round of systemic chemotherapy (second-line) after failure of primary chemotherapy treatment
  • Patients with mesothelioma tumors or cells in nearby lymph nodes
  • Patients qualifying for pre-surgical or post-surgical radiation therapy

Like all medical treatments, clinical trial participation comes with certain risks. Patients should discuss the potential benefits and risks of enrolling in a clinical trial with their oncologists.

Additional information on clinical trial safety, process, costs and enrollment can be found on our Clinical Trials Overview page.

02. List of Open Clinical Trials

List of Clinical Trials Recruiting Mesothelioma Patients

Provided below is a list of mesothelioma trials that are currently accepting new patients.

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)


Conditions: Mesothelioma

Last Updated: February 5, 2024

Status: Recruiting

Integrated Cancer Repository for Cancer Research (iCaRe2)


Conditions: Mesothelioma

Last Updated: August 9, 2023

Status: Recruiting

Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors


Conditions: Mesothelioma

Last Updated: March 10, 2023

Status: Recruiting

Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)


Conditions: Mesothelioma

Last Updated: November 1, 2022

Status: Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining


Conditions: Mesothelioma

Last Updated: October 27, 2022

Status: Recruiting

Rapid Autopsy and Procurement of Cancer Tissue


Conditions: Mesothelioma

Last Updated: October 26, 2022

Status: Recruiting

Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: October 25, 2022

Status: Recruiting

The Registry of Oncology Outcomes Associated With Testing and Treatment


Conditions: Mesothelioma

Last Updated: October 19, 2022

Status: Recruiting

A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors


Conditions: Mesothelioma

Last Updated: October 18, 2022

Status: Recruiting

Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs


Conditions: Mesothelioma

Last Updated: October 17, 2022

Status: Recruiting

Mass Response of Malignant Fluid Cells as a Biomarker for Rapid Therapy Guidance


Conditions: Mesothelioma

Last Updated: October 17, 2022

Status: Recruiting

Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: October 10, 2022

Status: Recruiting

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: October 10, 2022

Status: Recruiting

A Study of HFB200301 in Adult Patients With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: October 7, 2022

Status: Recruiting

A Study of CPI-0209 in Patients With Advanced Solid Tumors and Lymphomas


Conditions: Mesothelioma

Last Updated: October 6, 2022

Status: Recruiting

Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: October 5, 2022

Status: Recruiting

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: October 5, 2022

Status: Recruiting

Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma


Conditions: Mesothelioma

Last Updated: September 30, 2022

Status: Recruiting

Staging Procedures to Diagnose Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 28, 2022

Status: Recruiting

Stereotactic Magnetic Resonance Guided Radiation Therapy


Conditions: Mesothelioma

Last Updated: September 27, 2022

Status: Recruiting

A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer


Conditions: Mesothelioma

Last Updated: September 22, 2022

Status: Recruiting

A Phase II Clinical Trial to Evaluate Safety and Efficacy of XmAb20717 in Advanced Rare Cancers


Conditions: Mesothelioma

Last Updated: September 15, 2022

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-I


Conditions: Mesothelioma

Last Updated: September 10, 2022

Status: Recruiting

Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 8, 2022

Status: Recruiting

Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer


Conditions: Mesothelioma

Last Updated: September 1, 2022

Status: Recruiting

A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma


Conditions: Mesothelioma

Last Updated: August 26, 2022

Status: Recruiting

Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: August 25, 2022

Status: Recruiting

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors


Conditions: Mesothelioma

Last Updated: August 22, 2022

Status: Recruiting

APG-2449 in Patients With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: August 19, 2022

Status: Recruiting

A Beta-only IL-2 ImmunoTherapY (ABILITY) Study


Conditions: Mesothelioma

Last Updated: August 17, 2022

Status: Recruiting

Oral AMXT 1501 Dicaprate in Combination With IV DFMO


Conditions: Mesothelioma

Last Updated: August 15, 2022

Status: Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas


Conditions: Mesothelioma

Last Updated: August 12, 2022

Status: Recruiting

KZR-261 in Subjects With Advanced Solid Malignancies


Conditions: Mesothelioma

Last Updated: August 12, 2022

Status: Recruiting

Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion


Conditions: Mesothelioma

Last Updated: August 10, 2022

Status: Recruiting

A Study of NX-1607 in Adults With Advanced Malignancies


Conditions: Mesothelioma

Last Updated: July 27, 2022

Status: Recruiting

Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: July 26, 2022

Status: Recruiting

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers


Conditions: Mesothelioma

Last Updated: July 22, 2022

Status: Recruiting

Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: July 22, 2022

Status: Recruiting

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion


Conditions:

Last Updated: July 22, 2022

Status: Recruiting

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome


Conditions: Mesothelioma

Last Updated: July 11, 2022

Status: Recruiting

A Study of Pembrolizumab and Cryoablation in People With Mesothelioma


Conditions: Mesothelioma

Last Updated: June 16, 2022

Status: Recruiting

Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: June 7, 2022

Status: Recruiting

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer


Conditions: Mesothelioma

Last Updated: May 27, 2022

Status: Recruiting

A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers


Conditions:

Last Updated: May 20, 2022

Status: Recruiting


Conditions:

Last Updated: May 19, 2022

Status: Recruiting

Surgery for Mesothelioma After Radiation Therapy Using Exquisite Systemic Therapy


Conditions: Mesothelioma

Last Updated: May 19, 2022

Status: Recruiting

Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: May 18, 2022

Status: Recruiting

Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso)


Conditions: Mesothelioma

Last Updated: May 3, 2022

Status: Recruiting

Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery


Conditions: Mesothelioma

Last Updated: April 15, 2022

Status: Recruiting

Mesothelioma Stratified Therapy (MiST) : A Multi-drug Phase II Trial in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: April 7, 2022

Status: Recruiting

Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: April 4, 2022

Status: Recruiting

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers


Conditions: Mesothelioma

Last Updated: March 23, 2022

Status: Recruiting

CAR T Cells in Mesothelin Expressing Cancers


Conditions: Mesothelioma

Last Updated: March 10, 2022

Status: Recruiting

Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers


Conditions: Mesothelioma

Last Updated: March 4, 2022

Status: Recruiting

Glypican-1 Expression in Epithelioid Mesothelioma, Adenocarcinoma and SCC of the Lung


Conditions: Mesothelioma

Last Updated: February 8, 2022

Status: Recruiting

Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver, Gastrointestinal, Endocrine and Skin Toxicity


Conditions: Mesothelioma

Last Updated: January 31, 2022

Status: Recruiting

A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma


Conditions: Mesothelioma

Last Updated: January 28, 2022

Status: Recruiting

eRAPID: Online Symptom Reporting in Lung Cancer


Conditions: Mesothelioma

Last Updated: January 27, 2022

Status: Recruiting

Impact of Cardiac Coherence on Anxiety in Patients Operated on for a Peritoneal Carcinosis


Conditions: Mesothelioma

Last Updated: January 24, 2022

Status: Recruiting

Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma


Conditions:

Last Updated: January 14, 2022

Status: Recruiting

Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery


Conditions: Mesothelioma

Last Updated: January 5, 2022

Status: Recruiting

Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors


Conditions: Mesothelioma

Last Updated: December 2, 2021

Status: Recruiting

Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma


Conditions: Mesothelioma

Last Updated: December 8, 2021

Status: Recruiting

Stereotactic Body Radiation Therapy With Immunotherapy for the Treatment of Mesothelioma


Conditions: Mesothelioma

Last Updated: December 2, 2021

Status: Recruiting

Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: November 6, 2021

Status: Recruiting

Treatment of Malignant Peritoneal Mesothelioma (MESOTIP)


Conditions: Mesothelioma

Last Updated: November 4, 2021

Status: Recruiting

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors Enriched for Tumors With NF2 Gene Mutations


Conditions: Mesothelioma

Last Updated: November 2, 2021

Status: Recruiting

Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed


Conditions: Mesothelioma

Last Updated: October 15, 2021

Status: Recruiting

UNITO-001-A Phase II Study in HRR/PDL1 Positive MPM/NSCLC


Conditions: Mesothelioma

Last Updated: October 14, 2021

Status: Recruiting

Short Neoadjuvant Hemithoracic IMRT for MPM


Conditions: Mesothelioma

Last Updated: October 4, 2021

Status: Recruiting

PIPAC With Nab-paclitaxel and Cisplatin in Peritoneal Carcinomatosis


Conditions:

Last Updated: September 21, 2021

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-II


Conditions: Mesothelioma

Last Updated: September 14, 2021

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-III


Conditions: Mesothelioma

Last Updated: September 14, 2021

Status: Recruiting

Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies


Conditions:

Last Updated: September 13, 2021

Status: Recruiting

Real World Study of MPM in China


Conditions: Mesothelioma

Last Updated: September 13, 2021

Status: Recruiting

Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies


Conditions: None

Last Updated: September 13, 2021

Status: Recruiting

A Pilot Study to Explore the Role of Gut Flora in Metastatic Mesothelioma


Conditions: Mesothelioma

Last Updated: September 5, 2021

Status: Recruiting

Cardiac MRI Biomarker Testing (GCC 1618)


Conditions: Mesothelioma

Last Updated: August 16, 2021

Status: Recruiting

Efficacy of Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors


Conditions: Mesothelioma

Last Updated: August 13, 2021

Status: Recruiting

Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso)


Conditions: Mesothelioma

Last Updated: August 9, 2021

Status: Recruiting

Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: July 31, 2021

Status: Recruiting

SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II


Conditions: Mesothelioma

Last Updated: July 23, 2021

Status: Recruiting

Phase II Nivolumab and Ramucirumab for Patients With Previously-Treated Mesothelioma


Conditions: Mesothelioma

Last Updated: July 21, 2021

Status: Recruiting

Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies


Conditions: Mesothelioma

Last Updated: July 21, 2021

Status: Recruiting

Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma


Conditions: Mesothelioma

Last Updated: July 19, 2021

Status: Recruiting

The IMmunotherapy Pleural 5-ALA PDT


Conditions: Mesothelioma

Last Updated: May 18, 2021

Status: Recruiting

Olaparib in Patients With HRD Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: May 12, 2021

Status: Recruiting

BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: April 30, 2021

Status: Recruiting

Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours


Conditions: Mesothelioma

Last Updated: April 30, 2021

Status: Recruiting

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: April 28, 2021

Status: Recruiting

Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: April 15, 2021

Status: Recruiting

Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: April 12, 2021

Status: Recruiting

Oral TrkA Inhibitor VMD-928 for Treatment of Advanced Adult Solid Tumors or Lymphoma


Conditions: Mesothelioma

Last Updated: March 11, 2021

Status: Recruiting

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S


Conditions: Mesothelioma

Last Updated: March 8, 2021

Status: Recruiting

Pleurectomy/ Decortication (P/D) Preceded or Followed by Chemotherapy in Patients With Early Stage MPM


Conditions: Mesothelioma

Last Updated: March 5, 2021

Status: Recruiting

Pembrolizumab Plus Lenvatinib In Second Line and Third Line Malignant Pleural mesotheLioma Patients


Conditions: Mesothelioma

Last Updated: March 2, 2021

Status: Recruiting

Accelerated Hypofractionated Radiotherapy in the Treatment of Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: February 26, 2021

Status: Recruiting

DENdritic Cell Immunotherapy for Mesothelioma


Conditions: Mesothelioma

Last Updated: January 27, 2021

Status: Recruiting

Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: January 22, 2021

Status: Recruiting

Autologous Dendritic Cell Vaccination in Mesothelioma


Conditions: Mesothelioma

Last Updated: January 19, 2021

Status: Recruiting

Rehabilitation by Effort for Patients With Advanced Bronchial Cancer


Conditions: Mesothelioma

Last Updated: July 29, 2020

Status: Recruiting

αPD1-MSLN-CAR T Cells for the Treatment of MSLN-positive Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: July 28, 2020

Status: Recruiting

Combination of Immunotherapy and Hyperthermia in Advanced Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: July 14, 2020

Status: Recruiting

HMPL-453 in Advanced Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: June 16, 2020

Status: Recruiting

177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours


Conditions: Mesothelioma

Last Updated: May 5, 2020

Status: Recruiting

Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed


Conditions: Mesothelioma

Last Updated: December 13, 2019

Status: Recruiting

Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies


Conditions: Mesothelioma

Last Updated: December 11, 2019

Status: Recruiting

Mesothelioma and Radical Surgery 2


Conditions: Mesothelioma

Last Updated: October 28, 2019

Status: Recruiting

International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)


Conditions: Mesothelioma

Last Updated: October 7, 2019

Status: Recruiting