01. Common Symptoms
Common Symptoms of Mesothelioma
Some of the most common symptoms of mesothelioma include:
- Abdominal pain
- Chest pain
- Coughing or wheezing
- Difficulty breathing (dyspnea)
- Fatigue and muscle weakness
- Fever and night sweats
- Fluid buildup
- Loss of appetite
- Unexplained weight loss
Each patient will have their own unique experience. Identifying symptoms early may help doctors diagnose mesothelioma sooner. Mesothelioma is prone to late diagnosis, partly because of vague symptoms and a long latency period.
As a result, it is important for patients to seek medical care as soon as they notice symptoms. Early diagnosis can positively affect prognosis and treatment options.
02. Common Symptoms by Type
Common Symptoms of Mesothelioma by Type
One factor that can affect mesothelioma symptoms is the tumor location. Patients may experience different symptoms based on where the cancer originates (mesothelioma type). For example, trouble breathing may be a sign of pleural mesothelioma, which occurs in the lining around the lungs.
Common Symptoms of Pleural Mesothelioma
Malignant pleural mesothelioma develops in the pleura (linings around the lungs). Symptoms can often manifest as respiratory problems. Common pleural mesothelioma symptoms include:
- Chest pain
- Cough (regular and dry cough)
- Difficulty breathing
- Fatigue
- Loss of appetite
- Pain (any form)
- Pleural effusion
- Pleural plaques
- Pleural thickening
- Sweating (profusely)
- Weight loss
Pleural mesothelioma symptoms may be mistaken for those of the flu, bronchitis, pneumonia or lung cancer.
Common Symptoms of Peritoneal Mesothelioma
Peritoneal mesothelioma develops in the peritoneum (lining of the abdominal cavity). Most symptoms appear in the abdominal region. There are multiple organs within the abdomen. So symptoms can vary depending on which organs are near the tumor. Common peritoneal mesothelioma symptoms include:
- Abdominal distension (increasing size of the belly)
- Abdominal pain
- Ascites / peritoneal effusion
- Feeling full early
- Loss of appetite
- Nausea
- Pain (any form)
- Weight loss (may be substantial)
Peritoneal mesothelioma symptoms may be mistaken for those of irritable bowel syndrome (IBS) and Crohn’s disease.
Common Symptoms of Pericardial Mesothelioma
Pericardial mesothelioma develops in the pericardium, the lining around the heart. It is one of the rarest types of mesothelioma, accounting for less than 1% of diagnoses. Pericardial mesothelioma symptoms typically affect the chest region. Symptoms may appear to progress quickly because this form of mesothelioma is often diagnosed in late stages.
Pericardial mesothelioma symptoms may include:
- Cardiac tamponade (pressure on the heart from fluid buildup)
- Chest pain
- Dry cough
- Dysphagia (difficulty swallowing)
- Fatigue
- Pericardial effusion
- Pericardial thickening
- Right shoulder pain
- Shortness of breath
- Swelling of the legs or lower extremities
Pericardial mesothelioma is often misdiagnosed as coronary artery disease, heart failure or other heart-related cancers.
Common Symptoms of Testicular Mesothelioma
Testicular mesothelioma develops in the linings around the testes, called the tunica vaginalis testis. This type of mesothelioma is extremely rare, accounting for less than 1% of mesothelioma diagnoses. Common testicular mesothelioma symptoms can include:
- Enlargement of the scrotum (scrotal swelling)
- Hydrocele (fluid in the lining around the testicle)
- Inguinal mass (mimicking inguinal hernia)
- Solid scrotal mass (paratesticular mass)
- Spermatocele (fluid filled sac in the epididymis)
Testicular mesothelioma symptoms may be mistaken for those of a hernia or other testicular conditions.
Rare Symptoms of Mesothelioma
Less common symptoms of mesothelioma may include:
- Blood clotting issues
- Bone pain
- Coughing up blood
- Intestinal obstruction
- Nerve pain
Some symptoms common for one type of mesothelioma may be rare for other types.
Resources for Mesothelioma Patients
03. Common Symptoms by Stage
Common Symptoms by Mesothelioma Stage
Symptoms of mesothelioma may differ based on stage. Patients with stage 1 or stage 2 mesothelioma may experience milder symptoms than those with stage 3 or stage 4 mesothelioma. In general, stages 1 and 2 can be categorized as early-stage mesothelioma and stages 3 and 4 as later stages.
Early-Stage Mesothelioma Signs and Symptoms
Symptoms may be milder in the early stages of mesothelioma (stage 1 and stage 2). Early signs of mesothelioma can include:
- Abdominal pain or chest pain
- Difficulty breathing
- Fluid buildup
- Persistent cough
- Shortness of breath
It is not uncommon for early mesothelioma signs and symptoms to go unnoticed. This makes it vital for anyone with known asbestos exposure to watch for subtle changes in their bodies.
Identifying early warning signs of mesothelioma may help lead to an early diagnosis and improved prognosis.
Late-Stage Mesothelioma Signs and Symptoms
Symptoms may be more severe during the later stages of mesothelioma (stage 3 and stage 4). Late-stage mesothelioma symptoms may include:
- Abdominal pain or chest pain
- Difficulty breathing
- Fatigue
- Fluid buildup
- Persistent cough
- Severe or worsened pain
- Shortness of breath
- Weight loss
Some mesothelioma patients may not seek care until their symptoms have worsened. But a diagnosis is still helpful, no matter the stage. Doctors can recommend appropriate treatments and help ease patients’ pain or discomfort.
What Factors Influence Mesothelioma Symptoms?
Mesothelioma symptoms vary from patient to patient. Research has revealed some factors that can influence mesothelioma symptoms.
- Asbestos exposure: High levels of long-term asbestos exposure may cause symptoms to emerge sooner than infrequent, low-level exposure.
- Metastasis: Spreading to other tissues and organs may increase symptom severity or bring about new symptoms.
Mesothelioma specialists can help prepare patients for what symptoms they may expect. Patients should share all symptoms and symptom changes with their doctors to receive the best treatment and care.
04. How Symptoms Aid Diagnosis
How Do Symptoms Help With Mesothelioma Diagnosis?
Symptoms are often the reason patients seek a doctor’s help in the first place. So, doctors may start the diagnostic process by analyzing these symptoms. Early symptoms of mesothelioma can be mild or similar to those of common illnesses.
The diagnostic process may include a number of different tests or techniques, such as physical examinations, imaging scans like chest X-rays and blood tests. These are all done to rule out other conditions and determine which areas of the body are being affected. If symptoms and early tests suggest mesothelioma, a doctor can perform a biopsy to definitively diagnose mesothelioma.
Early detection can allow patients to undergo aggressive treatment options like surgery, which may improve mesothelioma prognosis. Once a patient has a diagnosis, their doctor and care team can determine which treatments to pursue.
05. Treating & Managing Symptoms
Treating Malignant Mesothelioma Symptoms
Mesothelioma treatment plans aim to slow or stop the cancer and help manage symptoms. Mesothelioma doctors review each patient’s unique medical history, diagnosis details and overall health. This helps them determine which treatments may have the best results.
Mesothelioma treatment types can be divided into two broad categories:
- Therapeutic treatments seek to help patients live longer. They often aim to remove as much of the cancer as possible. Therapeutic treatments may ease symptoms by addressing the condition that causes them.
- Palliative treatments seek to address symptoms, increase patient comfort and improve quality of life. Patients at any stage of mesothelioma can benefit from palliative care. One study found palliative cancer care can extend life expectancy by up to 6 months.
In some cases, a single treatment can offer both therapeutic and palliative benefits.
Therapeutic Treatments for Mesothelioma Symptoms
Therapeutic treatments are used to improve patient prognosis. Mesothelioma patients often receive multiple types of therapeutic treatments, a method known as multimodal therapy. Some of the most common therapeutic treatments for mesothelioma include:
- Chemotherapy: Drugs are administered to attack fast-growing mesothelioma cancer cells. For example, heated intraperitoneal chemotherapy (HIPEC) is a specific chemo treatment. During it, doctors administer a chemotherapy wash directly to the abdominal cavity.
- Immunotherapy: This treatment uses the patient’s immune system to attack cancer cells. For example, checkpoint inhibitors can help a patient’s immune system find, fight and kill cancer cells.
- Surgery: This method can fully or partially remove cancerous tumors and affected lymph nodes. Pleurectomy/decortication (P/D) is a common pleural mesothelioma surgery. It removes the cancerous lung lining and other tumors without fully removing the affected lung.
Other possible therapies include radiation therapy and experimental treatments.
Cancer treatments can remove or shrink cancerous tumors and tissues, which may help alleviate symptoms. For example, surgery may remove a peritoneal mesothelioma tumor. This can decrease pressure on organs in the abdomen, which can ease abdominal pain and reduce bloating.
Palliative Treatments for Mesothelioma Symptoms
Palliative care can be part of treatment for every stage of cancer. These therapies focus on easing symptoms and improving patient comfort and quality of life.
Some of the most common palliative treatments for mesothelioma are draining procedures to reduce effusions, or fluid buildup. This buildup puts pressure on nearby organs, which can cause discomfort and other symptoms. Draining this fluid can improve quality of life and ease symptoms.
Some common types of surgery to drain excess fluid include:
- Hydrocelectomy
- Paracentesis
- Pericardiocentesis
- Pleurocentesis / thoracentesis
Pleurodesis is also an option for preventing future fluid buildup. Pleurodesis is not a cure but can help manage and alleviate symptoms.
Doctors may also suggest a catheter to control fluid buildup. This may allow for continuous draining, which can alleviate associated symptoms.
Alternative Treatments for Mesothelioma Symptoms
Patients may find success with alternative treatments to manage symptoms. Alternative treatments may include things like acupuncture, yoga, massage therapy, physical therapy and nutrition management.
A good diet can help improve mesothelioma patients’ overall health, which may improve eligibility for more aggressive treatments. A nutrition plan may also help patients manage symptoms and side effects such as fatigue, weight loss and loss of muscle mass.
Patients should discuss potential alternative treatments with their medical care team. Mesothelioma specialists can confirm if it’s safe to add an alternative treatment to their existing plan.
Cost of Treating Mesothelioma Symptoms
Treatment costs vary depending on factors like diagnosis, treatment type, tumor location and insurance. In addition to the cost of diagnostic tests and treatment, patients may also have expenses related to traveling for treatment.
Different types of treatments often have different costs. For example, the average hospital cost for pleural cavity draining is $16,089. The average hospital cost for a pleurectomy is $53,993. Patients may also encounter unexpected costs connected to mesothelioma treatment.
Many resources and services are available to help manage these expenses. Insurance, legal compensation, charities, government assistance and disability benefits can all help reduce the financial burden of treatment.
06. Common Questions
Common Questions About Mesothelioma Symptoms
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What are the early warning signs of mesothelioma?
- Early warning signs of mesothelioma cancer include difficulty breathing, pain, fever, fluid buildup or unexplained weight loss. These symptoms may start mild and become more severe as the cancer progresses. Identifying these mesothelioma signs early on may help patients receive an early diagnosis.
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Can mesothelioma cancer cause fever?
- Running a fever may be a sign of many forms of cancer, including malignant mesothelioma. But fevers can also signal less serious conditions like a cold or stomach bug. Patients with risk factors for asbestos diseases should mention them to their doctors. This can help identify the true cause of vague symptoms, including a fever.
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How long do symptoms of mesothelioma take to develop?
- It can take anywhere from 10 to 50 years for mesothelioma symptoms to develop after exposure to asbestos. The average latency period across all ages, genders and types of mesothelioma is around 30 years.
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How do you know if you have mesothelioma?
- The first step to a mesothelioma diagnosis is speaking with a doctor or mesothelioma specialist. Depending on individual factors, like symptoms and a potential history of asbestos exposure, diagnostic tests may be performed. Doctors must test a biopsy tissue sample to confirm a mesothelioma diagnosis. Only a positive biopsy test result can tell you if you have mesothelioma.
